Studies show that rising incidence of metabolic and endocrine system diseases poses a major risk to global health. Drawing on extensive pre clinical experience in drug research for metabolic and endocrine disorders, JOINN has developed a full portfolio of metabolic disease models covering obesity, diabetes and its complications, hyperlipidemia, atherosclerosis, hyperuricemia and gout.
| Disease | Model | Species |
| Obesity | Diet induced obesity (DIO), spontaneous obesity | Mice/rats (including genetically modified animals) NHPs |
| Type 1 Diabetes Mellitus | STZ induced T1DM | Mice/rat NHPs |
| Type 2 Diabetes Mellitus | • Induced: STZ+HFD challenge • Spontaneous: db/db mice, ZDF rats, cynomolgus monkeys • Glucose clamp assay | Mice/rats Beagle dogs |
| Hyperlipidemia / Hypercholesterolemia | • Induced: high fat high sugar diet • Spontaneous: hyper-TG, Lp(a) dyslipidemia | ApoE mice Hamsters NHPs |
| Atherosclerosis | • High fat high sugar diet induction • High fat high sugar diet plus mechanical vascular injury | ApoE mice Rabbits NHPs |
| Hyperuricemia | Spontaneous hyperuricemia, induced hyperuricemia | UOX mic SD rats NHPs |
| Diabetic Nephropathy | STZ induction + nephrectomy + high-salt challenge | Rats |
| Delayed Diabetic Wound Healing | • STZ induced T1DM plus skin excisio • T2DM plus skin excision | Rats db/db mice ZDF rats |
| Diabetic Neuropathic Pain | STZ induced T1DM | Mice |
| Osteoporosis | Ovariectomy-induced osteoporosis | Rats |
