Studies indicate that rising incidence of central nervous system diseases represents one of the greatest global health‑related risks. JOINN’s CNS disease research team has extensive experience in preclinical research for CNS‑targeted therapeutics. We have established a comprehensive panel of CNS‑relevant disease models, including stroke, Alzheimer’s disease, Parkinson’s disease, depression, schizophrenia, pain and epilepsy.
| Disease | Model | Species |
| Alzheimer's Disease | APP/PS1 transgenic mice, 5XFAD transgenic mice | Mice |
| Parkinson's Disease | • 6-OHDA-induced PD mode • MPTP-induced PD model • A53T transgenic mice | Mice, Rats, NHPs |
| Depression / Anxiety | Forced swim test, tail suspension test, open field test, elevated plus maze, m-CPP-induced anxiety-like behavior | Rats/Mice |
| Epilepsy | PTZ-induced acute & chronic epilepsy (rats); kainic acid intrahippocampal chronic epilepsy (NHPs) | Rats, NHPs |
| Pain | Traumatic pain, inflammatory pain, neuropathic pain, disease-associated pain (cancer pain, arthritic pain) | Rats/Mice, minipigs, dogs, NHPs |
| Stroke | Ischemia-reperfusion stroke, permanent ischemic stroke, hemorrhagic stroke | Rats, NHPs |
| Traumatic Brain Injury (TBI) | Controlled cortical impact model | Rats |
| Spinal Cord Injury | Spinal cord contusion model | Rats, NHPs |
| Neurovirulence Assessment | Poliovirus, herpesvirus, measles, mumps, rubella virus models | NHPs |
| Sleep / Sedation / Anesthesia | Righting reflex, spontaneous activity, sedation scoring, telemetric EEG | Rats/Mice, minipigs, dogs, NHPs |
| Dependence Liability Test | Spontaneous withdrawal, precipitated withdrawal, conditioned place preference, self-administration, drug discrimination | Rats |
| Rare Diseases | • ALS: SOD1-G93A, Prp-TDP43A315T • DMD: Dmd em1(Q995X) Smoc • Phenylketonuria: Pah KO • SMA mice | Mice |
