Studies indicate that rising incidence of digestive system diseases represents one of the greatest global health‑related risks. JOINN’s digestive system disease research team has extensive experience in preclinical research for digestive‑targeted therapeutics. We have established a comprehensive panel of digestive‑relevant disease models, including inflammatory bowel disease, gastric ulcer, pancreatitis, fatty liver, liver cirrhosis, irritable bowel syndrome, gastrointestinal tumors and others.
| Disease | Model | Species |
| Acute Gastric Ulcer | Cold restraint stress, histamine induction, ethanol induction | Rats |
| Metabolic Dysfunction-Associated Steatohepatitis (MASH) | • Diet induction (MCD, CDAHFD, GAN, HFD) • Chemical induction: CCl4, STZ • Genetic models: db/db, ob/ob • Combined induction: STAM, CCl4+HFD | Mice, Rats, Hamsters, NHPs |
| Hepatitis / Liver Fibrosis / Cirrhosis | • Chemical induction: CCl4, TAA • Bile duct ligation • Combined induction: ethanol + CCl4 + HFD | Mice, Rats |
