Studies indicate that rising incidence of inflammatory and autoimmune diseases represents one of the greatest global health related risks. JOINN’s inflammatory & autoimmune disease research team has extensive experience in preclinical research for therapeutics targeting inflammatory and autoimmune disorders. We have established a comprehensive panel of inflammatory and autoimmune relevant disease models, including rheumatoid arthritis, systemic lupus erythematosus, ulcerative colitis, experimental autoimmune encephalomyelitis, psoriasis, allergic dermatitis, graft versus host disease, sepsis and others.
| Disease | Model | Species |
| Rheumatoid Arthritis | CFA induced, collagen induced, spontaneous arthritis | Rats/Mice, NHPs |
| Systemic Lupus Erythematosus (SLE) | Spontaneous MRL/Lpr mouse model | Mice |
| Ulcerative Colitis | DNBS induced, TNBS induced, DSS induced colitis | Rats/Mice, NHPs |
| Experimental Autoimmune Encephalomyelitis (EAE) | MOG35-55 induced EAE, PLP139-151 induced EAE | Mice |
| Psoriasis | Imiquimod induced model | Mice |
| Atopic Dermatitis | DNCB, DNFB induction | Mice |
| Graft versus Host Disease (GvHD) | hPBMC-induced GvHD | NOD/SCID, NSG, B-NDG mice |
| Sepsis | LPS challenge, cecal ligation and puncture (CLP) | Rats/Mice |
