JOINN has established core reproductive disease models including asthenospermia and primary ovarian insufficiency, as well as urinary system disease models such as renal injury and renal fibrosis, to support R&D of reproductive therapeutics and assisted reproduction related studies. Pharmacodynamic evaluation is available for small molecule drugs, antibodies, vaccines and nucleic acid therapeutics.
Reproductive System Disease Models
| Disease | Model | Species |
| Asthenospermia | Busulfan induction, heat stress induction, cryptorchidism model | Mice |
| Primary Ovarian Insufficiency | VCD induced ovarian insufficiency | Rats |
Urinary System Disease Models
| Disease | Model | Species |
| Acute Kidney Injury (AKI) | Unilateral renal ischemia reperfusion injury, chemotherapy induced AKI, ureteral ligation | Mice, Rats |
| Chronic Kidney Disease / Renal Fibrosis | 5/6 nephrectomy, gentamicin induction, adenine induction | Mice, Rats, NHPs |
